Anti-Inflammatory/Antipyretic

Chronic Joint Inflammation

•    Mouse Type II Collagen (CIA) and SCW Arthritis
     Mouse Adjuvant Arthritis
     Cytokine Analysis, Histopath, X-ray analysis, Joint Swelling

Acute Paw Inflammation

•    Mouse Carrageenan and Oxazolone Paw Edema
     Mouse Zymosan Paw Edema
     Cytokine Analysis

Acute Air Pouch Inflammation

•    Mouse & Rat (Carrageenan, Chemoattractant, TNF-a, IL-1b, Superantigens)
     Cytokine Analysis, Cell Number, and Cell Phenotyping (Cytospin & FACS)

Acute Inflammation

•    Mouse LPS-induced inflammation (local and systemic)
     Mouse LPS/D-Gal-induced mortality
     Cytokine Analysis

Delayed Type Hypersensitivity (DTH)

•    Mouse air pouch model with chemoattractants, superantigens, and toxins
     Mouse intraperitoneal migration model with Chemokines, superantigens,
       toxins and Oxazolone
     Mouse and Minipig Th1 and Th2 DTH and ACD skin migration model
     Cytokine Analysis, Cell Migration, Ex Vivo Cell Proliferation

Asthma

•    Mouse Ovalbumin asthma model
     Mouse Cockroach asthma model
     Cytokine Analysis

Diabetes Type I and Type II

•    Mouse
     Rat
     MiniPig

Wound Healing

•    Rat
     MiniPig (deep wounds, long term)

Chronic CNS Inflammation

•    Mouse Experimental-Induced Encephalomyelitis (EAE) (Acute B6 Mice, SJL,
       Biozzi Mice)
     Spontaneous EAE mouse B6/RAG/TR model
     Cytokine Analysis, Cell Proliferation

Gastrointestinal Inflammation/Irritation

•    Colonic Inflammation: Mouse Dextran Sulfate and Oxazolone Models
     Acute Gastric Irritation in mice (4 hr)
     3-day Intestinal Irritation in mice (72 hr)
     Cytokine Analysis, colon assessment and histopath

Oncology Models

•    Tumor Implants
     Human xenografts in nude athymic mice
     Orthotopic and ectopic implantation
     Leukemia models (NOD/SCID)
     Induced Metastasis Models
     Spontaneous metastasis
     Orthotopic and footpad implantation

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