HTS enables scientists to rapidly assay thousands of compounds in search of biological activity for drug discovery. The drug discovery process begins with the identification of biological molecules that are involved in disease (disease targets) and the synthesis of chemical compounds (drug candidates), which may be able to act on these targets. Scientists screen biological samples, using HTS, to identify compounds worth pursuing as drug candidates. HTS is one of several tools pharmaceutical and biotechnology companies have to employ to find leads for drug candidates or to conduct basic biological research. Bio-Quant has multiple signaling and functional HTS assays including, calcium and ipH fluxes, chemotaxis, shape changes and ligand-receptors interactions.

Figure 1: Jurkat cells loaded with Indo-1/AM were stimulated with increasing concentration of SDF-1alpha and the changes in fluorescence (indicative of calcium levels) were recorded using the Sci Imager device. Each treatment was performed in duplicate, and data updates were taken every second. The data from the duplicates illustrate the data fidelity obtained using the Sci Imager device.
top |















top